Abstract: This study aimed to investigate the protective and therapy effect of apple peel as food additives which may be due to increase the efficiency of the immune system or reactivity it in experimental animals. Results showed that all Gs recorded significant increases in body weight, food intake and food efficiency in the experimental period. G (1) gave significant increases in body weight, food intake and food efficiency when compared to G (2) during the first three weeks. The relative percentage of spleen weight was increased significantly in Gs (1&2) when compared to control Gs. G (1) gave insignificant increases in percentage of spleen weight when compared to G (2). RBC's count was significantly decreased in G (1) when compared to (Co+). The same results were noticed for levels of Hb and Hematocrit when compared to (Co+). The RBC's, Hb and hematocrit count was increased in weeks (0, 2, 4 and 6), in G (2). G (2) gave increases in RBC,s , Hb and HCT in week 6 and G (1) gave decrease in MCV, MCH. The level of PLT and PCT were increased in G (1). Significant increases in Granyolocyte were detected in G (1) when compared to (Co+). The Monocyte % and Granyolocyte were increased significantly in weeks 4 and 6 when compared to (Co-) in week 6. Urea, BUN and creatinine level were decreased in G (1), BUN/creat. Ratio gave significantly increase when compared to (Co+). Urea level and BUN was higher in week 0 and decrease gradually in week 2, 4 and 6 in G (2). G (2) gave significant increases in urea and BUN /creat. Ratio compared to G (1). Level of AST, ALK and ALK were significantly decreased in G (1) when compared to (Co+). ALT level was slight increased in serum samples of G (1) when compared to (Co+). AST level was significantly decreased in serum samples of weeks 2,4 and 6. Similar result was found in G (2). In T.protein and T. globulin contents were increased in G (1) and the level of T. Albumin and A/G Ratio were decreased when compared to (Co+). T.protein was increased in week 0 and 2. The level of T. Albumin was increased in G(2) in week 0. T. Albumin was decreased after 2, 4 and 6 weeks in G (2) and slight decreases in the level of T. globulin in G (2) in weeks 0, 2, 4 and 6 when compared to (Co-). Increases were found in T. Protein and T. Albumin in G (2) when compared to G (1). IgG levels in group (1) was significantly increased. Also, slight increase in IgG ratio of T. P. was detected in group (1) when compared to (Co+). IgG levels and IgG Ratio of T. Protein in group (2) were decreased when compared to (Co-) in week 0 and 2, significant increase was detected in weeks 4 and 6. Diet reduced the MDA in Gs(1&2) when compared to control group. When compared between two experiments group (1) gave decrease in level of MDA this indicator to the feeding before stress was the best. Results of the present study recommend that the important role to apple peel where hence they play a good role in raising the efficiency of the immune system and body protection against diseases. However, Millions of pounds of waste apple peels are generated in the production of applesauce and canned apples each year. We proposed that a valuable food ingredient could be made using the peels of these apples if they could be dried and ground to a powder without large losses of phytochemicals and use it as food additive to support and production functional food. Key words: protective and therapy effect, Apple peel, Immune system, experimental rats suppressed, stress.