The purpose of the present study was to investigate using an online self-regulation based vocabulary learning program to improve secondary stage EFL students reading comprehension. To fulfill the purpose of the study, four instruments were constructed; an Online Reading Comprehension Skills Questionnaire was designed to determine reading comprehension -skills that EFL secondary stage students need, a Pre-post Online Reading Comprehension Test, an Online Vocabulary Strategies Inventory, and an Online Self regulation Strategies Scale. The validity and reliability of the study instruments were established before their use in the study. The study adopted the quasi-experimental design. The sample of the study consisted of 60 EFL first grade secondary stage students. They were randomly selected from Bahbeet Alhegara Secondaray Scool at Samanoud Educational Zone in Gharbia where 30 student represented the experimental group and 30 represented  represented the control group. The online self regulation based vocabulary learning program was administered to the experimental group for 8 weeks whereas the control group received the conventional teaching. Results of the study revealed that online self regulation based vocabulary learning program led to significant improvement in first grade secondary stage student EFL online reading comprehension skills. A number of recommendations concerning the use self regulation strategy training, vocabulary strategy training, and online reading comprehension were presented. Key words: Online Program, Reading Comprehension, Self regulation Strategy, Vocabulary Strategy.