Background: Chronic kidney disease has become a major chronic health problem worldwide and the need for development of educational interventions which help patients to better manage their conditions is evident internationally. It has been recognized that poor adherence can be a serious risk to the health and wellbeing of patients. Adherence to fluid restrictions, dietary and medication guidelines as well as attendance at prescribed hemodialysis sessions are essential for adequate management of chronic kidney disease. Purpose to examine the effect of nursing intervention on controlling interdialytic weight and vascular access complications among patients undergoing hemodialysis. Setting: Hemodialysis unit in Menoufia University and Shebin El-Kom Teaching Hospitals. Sampling: A consecutive sample of 100 adult patients on hemodialysis were selected and divided alternatively into two equal groups: 50 patients for each group (study - control). Instruments: two instruments were used for data collection: Structured interview questionnaire, and biophysiological measurement instrument. Results: There was significant improvement among study group than control group one month and three months post intervention regarding total knowledge score, interdialytic weight and vascular access complications. Conclusions: Nursing intervention is proven to be effective in controlling interdialytic weight and vascular access complications. Recommendations: Supervised nursing intervention should be carried out for all hemodialysis patients and colored booklet should be available and distributed for all patients.