The COVID-19 outbreak has challenged the global tourism economy. It has particularly threatened the survival of travel agencies in developing countries, especially those with the greatest growth of international visitors, such as Egypt. Resilient organizations are proactive and recover better from hardship. Resilience is more than just recovery; it also implies a certain level of flexibility and the ability to adapt to both positive and negative influences of the environment. Employees are acknowledged as a critical dimension in tourism and hospitality services. So, this study focused on Examining the resilience of the human resource practices in the travel agencies  category (a) in Luxor and Aswan during Covid-19 pandemic. Moreover, it aims to determine the factors which affect the resilience of the human resources practices in travel agencies in Covid-19.  On the other hand, investigate the procedures put by the government to help travel agencies overcome the challenges they face during Covid-19 pandemic.  The Data was obtained from a questionnaire initiated with managers of selected travel agencies in Luxor and Aswan. The data were analyzed using SPSS ver. 22. The survey results demonstrated that there was no resilience in applying most of human resources practices in travel agencies during Covid-19 pandemic. Few practices related to safety and hygiene were applied . The Egyptian government put many procedures to help travel agencies facing the risks due to Covid-19. The results contributed to an understanding of how HR practices can sustain the tourism workforce and enhance resilience in the face of a global pandemic.