The purpose of this study was to evaluate the ESP course (Eng 201) which is taught as an advanced level to 2^nd and 3rd years to Applied Medical Sciences College at Misr University for Science and Technology (MUST) in Fall 2015 semester. The text book is called "English for Nursing". But in addition to Nursing, there are three other departments;  Radiology, Laboratory, Respiratory.  So, the text book seems to be irrelevant to most of the students' specialization. Three instruments including :a questionnaire , an interview, and a needs checklist were used. The results of the questionnaire and the interview showed that most of the students of both 3rd  & 4^th years who registered in the course (Eng 201) Applied were not satisfied with the text book. The analysis of the needs checklist showed that the most prominent needs most of the students agreed on were: acquiring some of the terminology that can help them in their study, some expressions and some language functions to help them communicate effectively   with their lecturers, and their colleagues solving listening and speaking problems in English