The present study explores the relationships between person-organization fit, job satisfaction and turnover intention empirically in the private higher education sector in Egypt, based on a survey of academic staff of October University. It has been realized that all dimensions of person –organization fit (Value congruence. Goal congruence) have positively relation with job satisfaction and negatively relation with  turnover intention. Moreover, job satisfaction mediates the relationship between person organization fit and turnover intention.Finally, the survey findings suggest that; It is certain that job satisfaction will mediate the relationship between the person-organization fit and turnover intention. The person-organization fit (in terms of value and goal congruence) will provide greater importance, which will then lead individuals to a higher level of employee job satisfaction. In the long run, individuals with a higher level of job satisfaction would be less likely to leave the organization .finally  It is  necessary for organizations to consider the relationship between (P-O) fit,  job satisfaction  and turnover intention in the formulation, Developing and maintaining  of their retention strategies