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106944

The protective effect of Coriandrum sativum L. oil against liver toxicity induced by Ibuprofen in rats.

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Last updated: 25 Dec 2024

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Abstract

Ibuprofen (IBU) is a Non-steroidal anti-inflammatory drugused in the treatment of pain, fever and in inflammation.Coriandrum sativum is cultivated for its aromatic and medicinal uses. The present study aims to evaluatethe protective effect of Coriandrum sativum volatile oil on hepatotoxicityof IBU in rats. Five groups of albino rats were used.Group l(control),groupll (C.sativum oil,40 mg/kg B.W. for 14 day), group lll (IBU group,100mg/kg bodyweight B.W., for 14 day), group lV (IBU+ C.sativum oil) and groupV (recovery group).The activity of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were measured in the liver of different groups addition to the histological examination of the sections of liver. The results showed that IBU caused a significant decrease in the activity of ALT and AST in the liver. The histological examination of the liver showed many pathological changes. Administration of coriander volatile oilin the combination with IBU was able to significantly increase the activity of both AST and ALT, in the liver and caused a significant decrease in the deleterious effect induced by IBU. The present results confirm that the antioxidant activity of volatile oil of the Coriandrum sativum L., against hepatotoxicity of IBU

DOI

10.21608/jbaar.2016.106944

Keywords

Ibuprofen, Liver, Coriandrum sativum, histopathology, transaminases

Authors

First Name

Hoda H.

Last Name

Baghdadi

MiddleName

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Affiliation

Department of Environmental Studies, Institute of Graduate Studies and Research, Alexandria University

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First Name

Fatma M.

Last Name

El-Demerdash

MiddleName

-

Affiliation

Department of Environmental Studies, Institute of Graduate Studies and Research, Alexandria University

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Orcid

-

First Name

Sodfa

Last Name

Hussein

MiddleName

-

Affiliation

Department of Environmental Studies, Institute of Graduate Studies and Research, Alexandria University

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-

City

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Orcid

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First Name

Eman H.

Last Name

Radwan

MiddleName

-

Affiliation

Zoology Department, Faculty of Science, Damanhour University

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-

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Volume

2

Article Issue

3

Related Issue

16188

Issue Date

2016-03-01

Receive Date

2016-02-20

Publish Date

2016-03-01

Page Start

197

Page End

202

Print ISSN

2356-9174

Online ISSN

2356-9182

Article File

JBAAR_Volume 2_Issue 3_Pages 197-202.pdf

PDF . 823.7kB

Link

https://jbaar.journals.ekb.eg/article_106944.html

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https://jbaar.journals.ekb.eg/service?article_code=106944

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Original Article

Type Code

1,272

Publication Type

Journal

Publication Title

Journal of Bioscience and Applied Research

Publication Link

https://jbaar.journals.ekb.eg/

MainTitle

The protective effect of Coriandrum sativum L. oil against liver toxicity induced by Ibuprofen in rats.

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Article

Created At

22 Jan 2023