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129861

EFFECT OF CAMELS MILK FEEDING ON OXIDATIVE STRESSES IN EXPERIMENTALLY INDUCED DIABETIC RABBITS

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Last updated: 22 Jan 2023

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Abstract

Diabetes mellitus is a multi-factorial disorder that CHARacterized by hyperglycemia, lipoprotein abnormalities resulting from malfunction in insulin secretion and/or insulin action causing impaired metabolism of glucose, lipids and protein. In addition, generation of free radicals often worsen the complications of diabetes mellitus such as hypertension, atherosclerosis and microcirculatory disorders. A group of scientists reported the effect of camel milk on diabetes, referring to its importance in treatment of diabetes and patients who drink camel milk daily, their need to insulin decrease. Therefore, this study aimed to throw light on the effect of camel milk in comparison to insulin treatment. This study was carried out on forty male New Zealand rabbits, divided into four equal groups each group contained ten rabbits. The first group (G1) was considered as control non diabetic group injected with normal saline solution. The other animals were injected intravenously with alloxan for induction of experimental diabetes mellitus and then divided into three equal groups ten rabbits each as the follows: (G2) considered as control diabetic left untreated, (G3) was considered as diabetic insulin treated group, (G4) was considered as diabetic camel milk treated group. After the end of the experiment (4 weeks), blood (whole blood & serum) in addition to tissue samples (liver, kidney and pancreas) were collected from all the animals for analysis of: enzymatic SOD and catalase, non-enzymatic GSH antioxidant enzyme activities. Serum malondialdeyde, glucose, insulin and lipid profile.It was observed that the effect of camel milk containing insulin like peptides, vitamin C and zinc in addition to other minerals and vitamins that are effective in the treatment of diabetes in comparison to insulin treatment alone. In addition to its hypoglycemic effect and improvement of oxidative stress accompanied with diabetes mellitus.It was observed that there is regeneration in  cells and S.Sherbini. et.al., 76 high number of islets of Langerhans among the pancreatic acini in rabbits receiving camel milk. There is a wide similarity between camel milk and goat milk. So, from this study, camel milk administration in case of insulin dependant diabetes mellitus is recommended as oral anti diabetic drug. ,

DOI

10.21608/mvmj.2016.129861

Authors

First Name

Tantawy

Last Name

Esraa

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First Name

Sherbini

Last Name

S.

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First Name

El-Sayed

Last Name

G.R.

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Volume

17

Article Issue

2

Related Issue

19229

Issue Date

2016-06-01

Receive Date

2016-04-15

Publish Date

2016-07-01

Page Start

1

Page End

20

Print ISSN

1110-7219

Online ISSN

2682-2512

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https://mvmj.journals.ekb.eg/article_129861.html

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https://mvmj.journals.ekb.eg/service?article_code=129861

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46

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Journal

Publication Title

Mansoura Veterinary Medical Journal

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https://mvmj.journals.ekb.eg/

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Article

Created At

22 Jan 2023