Pots and field experiments were conducted in Ismailia, Agric. Res. Station, to evaluate the impact of some strains of plant growth promoting rhizobacteria (PGPR) (Azotobacter chroococcum, Azoupirillum brasilense, phosphate solubilising bacteria (Bacillus megaterium var. phosphaticum), potassium   solubilising   bacteria (B. cereus, B. polymyxa and Pseudomonas fluorescens)for their efficacy against Fusarium oxysporum on lupine plants in pots, all tested PGPR significantly decreased wilted plants and increased healthy plants compared with the control treatment. P. fluorescens was the most effective in controlling wilt disease and increasing the levels of total, free and conjugated phenol in lupine followed by B. polymyxa and B. megaterium. While, A. brasilense was the least one. In the field trial during 2008/2009 and 2009/2010 growing seasons, results indicated that, P. fluorescens treated plots reduced wilt disease incidence of lupine plants resulting in a significant increase of lupine plant growth and seed yield compared to the control treatment.