Isolation trials from the rotten roots of soybean roots collected from three Egyptian governorates, i.e. Giza, Menoufia and Gharbia yielded many fungal isolates. The isolated fungi were purified and identified as Alternaria spp., Fusarium moniliforme, Fusarium oxysporum, Fusarium semitectum, Rhizoctoniasolani and unknown fungi. Laboratory, greenhouse and field studies were conducted to study the effect of two natural extracts and antioxidants in comparison with two fungicides on the reduction of damping-off and root-rot diseases. In vitro studies showed that these treatments significantly reduced the linear growth of the tested fungi compared with control treatment.Greenhouse experiment revealed that all the tested treatments significantly reduced damping-off and root-rot compared to the untreated plants. The most effective treatment was obtained by the extracts of neem and Eucalyptus followed by the antioxidants salicylic and oxalic acid, which reduced both damping-off and root-rot diseases. Crop parameters, i.e. plant height, number of branches, number of pods, seed yield / plant, weight of 100 seed as well as the average weight of seed yield (kg)/plot, were recorded at harvest. Also, total N and crude protein in the seeds were greatly increased due to the tested treatments as well as the treatment with two fungicides: Vitavax-T and Monceren.