This study aims to investigate the direct and indirect effect of high-performance work systems and career adaptability through the mediating role of creative self-efficacy in Damietta banks' employees. A questionnaire was used to collect data from 257 banks' employees. Structural equation modeling was employed to show the causal relationships between study variables. The findings of the current study revealed that high performance work systems have a significant direct positive effect on creative self-efficacy. Moreover, creative self-efficacy has a significant direct effect on career adaptability. Additionally, the findings also showed that high performance work systems have a significant direct positive effect on career adaptability. Finally, the results revealed that creative self-efficacy mediates the relationship between high performance work systems and career adaptability.