Water salinity is a limiting factor stressed plants and associated with low wheat productivity in new reclaimed areas in Egypt such as North Sinai. Sea water is ​​available water resources and renewable and non-exploited, it is necessary to maximize use of this water through scientific research for use in irrigation of wheat, to increase the cultivated area and thus, increase production towards self-sufficiency. So, two field experiments were carried out at Faculty of Environmental Agricultural Sciences, EI- Arish, Suez Canal University, during 2012/2013 and 2013/2014 seasons aiming to investigate the response of three wheat cultivar (Triticum aestivum. L.; Masr₁, Masr_2, Sakha₉₃) to four mixing ratios between well-water and sea water (control, 3:1, 2:1 and 1:1). Plants were subjected to salinity treatments at 60 days after sowing (DAS). Results showed that Masr₂ and Masr₁cvs were superior for yield and its attributes, the superiority was obtained from Masr₂ cv as well as seed content of proline and protein. Also, dry leaf content of Na⁺ and Cl^-2 were higher for Masr₂ as compared to the other studied cultivars under low mixing ratio (3:1 Well water: Sea water), while, the K⁺ concentration was decreased with the same treatment of Masr₂. For soil analysis, EC, Na⁺, Mg⁺², K⁺, HCO₃^-2 and Cl^- increased but Ca^-2 decreased under the highest mixing ratio (1 Well water: 1 Sea water). So, it could be recommended to cultivate Masr₂ wheat cultivar under North Sinai conditions, using mixing ratio 3 Well water : 1 Sea water to maximize the benefit of sea water and gain economic productivity of bread wheat in this area and similar regions.