ABSTRACT Two field experiment were layout in the calcareous soils of privet farm, Behera Government, Egypt during the two summer seasons (2019 and 2020) to evaluate the response of two soybean varieties (Giza 111, Giza 22) to organic and bio fertilizers as well as to replacement part of using mineral nitrogen fertilizers and inoculated with specific bradyrhizobium japonicum with two levels of compost (6 and 9 ton per fad) or with two rate of compost tea (5 and 10 L per fad) in presence of rational nitrogen mineral fertilizer (20 k N per fad). The obtained results revealed that application of organic and bio fertilizers + 20 kg N fad did support plant growth parameters and led to scored higher values for plant height, number of branches, plant dry weight, number and dry weight of nodules and N, P and K plant contents (%), as well as earliest in flowering days. The best treatments comparison with recommended (N, P and K ) at treatment of applying compost tea in the two rates of organic fertilizer in presence of bio fertilizer with 20 kg N per fad were obtained significantly increased and gave the highest values for number. of pods per plant (75.2 – 68.3), seed yield per plant (24.8 – 18.7 g), 100-seed weight (16.4 – 13.4 g) and seed yield per fad (1.740 – 1.335 ton) for variety Giza 111 and Giza 22, respectively. Variety Giza 111 was superior as in all studied characters compared to Giza 22 variety.