ABSTRACT Garciniacambogia (GC) extract and its active component hydroxycitric acid (HCA) have been used to reduce cholesterol and triglycerides. It is also available with other effects, such as improvement of glucose tolerance and of blood pressure. The aim of the present study was to evaluate the effect of Garciniacambogia fruit powder and its water extract on obese rats. Forty two adult male albino rats (Sprague-Dawley strain), weighing about (200±10g) were divided randomly into two main groups as follow: the first group (-Ve control= 6 rats) was fed on basal diet. The second group (36 rats) was fed on high fat diet (HFD) for 4 weeks then divided equally to 6 groups from group 2 to group 7. Group 2 (+Ve control) fed on basal diet. Group 3, 4 and 5 fed on basal diet supplemented with 5%, 10% and 15% GC waterextract, respectively. Also, group 6 and 7 fed on basal diet supplemented with 5% and 10% GC powder, respectively. At the end of the experimental period (4 weeks), rats were scarified and serum was collected to determine lipid profile, glucose and leptin levels. The results showed that the body weight of rats and serum levels of total cholesterol, triglyceride, LDL-C, VLDL-C, leptin and glucose were significantly elevated (P