ABSTRACT Field experiments were carried out at El-Mattana Research Station (latitude of 25.25°N and longitude of 32.31°E), Agricultural Research Center, Luxor Governorate, Egypt, in plant can and 1st ratoon crops grown during 2016/2017 and   2017/2018 seasons to study the effect of different herbicides and hand hoeing on weeds in sugarcane varieties (G.T.54-9, G.2003-47 and G.2003-49) .The treatments were Starane (fluroxypyr 20 % EC)and Lumax (s-metalachlor +atrazine + mesotorine 53.75 % WP) applied as pre-emergence ,whereas Garlon (triclopyr 20 % EC) and Clomedy (clomazone 50 % EC)applied as post-emergence and hand hoeing twice at 30 and 45 days after planting in comparison with untreated control. Obtained results showed that the predominant broad-leaved weeds wereAtropa belladonna, convolvulus arvensis, Corichorius olitorius, Euphorbia astiqourumand and portulaca oliricea,  in sugarcane field during the two studied seasons. Results also indicated that all the tested herbicides and hand hoeing significantly gave high weed control efficiency of weeds as well as highest increase in cane growth, yield and quality of sugarcane over untreated control. Among the tested herbicidal treatments , Lumax, Garlon and Starane showed maximum herbicidal activity against broad-leaved weeds, improve cane growth, and increase yield and quality of sugarcane varieties in sugarcane field than the other treatments compared to weedy check.