This research aimed at examining the effect of a proposed infographics-based ESP course on enhancing graduate nursing students' critical reading skills and their motivation towards reading. The sessions of the ESP course were designed following the pre-while-post reading phases. The course made use of genuine/authentic reading texts and infographics in addition to some tools such as Facebook, Piktochart and Padlet for helping students to interact, design and publish their infographics. Besides, multiple tasks for encouraging students' discussion, collaboration and critical thinking were provided. Participants included one hundred students enrolled in the second year of the specialized nursing diploma, Faculty of Nursing, Mansoura University. The quasi-experimental design was adopted in which the participants were assigned into two groups: a control group (studied through the regular English course) and an experimental group (studied through the ESP course based on infographics). Instruments used in the research were a critical reading skills questionnaire, a criteria checklist for infographics use and design, a critical reading skills test and a reading motivation scale. Results revealed that the experimental group students outperformed their counterparts of the control group in the target critical reading skills. Besides, the students' post motivation level of the experimental group was enhanced compared to their pre-level and to the control group's post motivation level as well. As a result, the ESP course based on using infographics proved its significant effect on enhancing the graduate nursing students' critical reading skills and motivation towards reading.