This study was conducted during seasons 2019 and 2020 at a private farm situated at Nag Hammadi district, Qena Governorate, Egypt, to study stimulate the ability of the Balady Mandarin tree to tolerate climate changes and improve the growth, yield, and characteristics of the fruits through the appropriate agricultural practices by supplying trees with bio-stimulants via soil in addition to spraying some anti-stress substances. The results showed that adding bio-stimulants to trees via soil at twice in the (end of February and mid-May) in addition to foliar spraying with some anti-stressors such as (amino acids or potassium silicate or hydroxybenzoic acid). At 0.1% four times in the first of March and middle of (May, June, and July) led to enhancing the tree's ability to withstand environmental disturbances and improving in all vegetative growth characteristics and leaf content of chlorophyll, nitrogen, and phosphorous as well as the nutritional status of trees and this was positively reflected on increasing the yield and fruit quality characteristics compared to untreated trees which recorded the lowest values for all studied traits. And there were no significant differences between the three anti-stressors. So, it can be recommended to use bio-stimulants via soil and spraying of any of the anti-stress that studied as part of an agricultural strategy to overcome the negative effects of climate change, which is highly dependent on plant nutritional status.