Subterranean termites Psammotermes hypostoma (Desneux) has become a major pest in Egypt. To investigate new effective and inexpensive ways of control this pest, we assessed nanoparticles synthesized by a green approach using corresponding salt (sliver nitrate) with aqueous extract of garlic, chili, turmeric, and black pepper were commercially purchased. UV–visible wavelength scanning and nanoparticle tracking analyses were used to determine the quantity and quality of nanoparticles. The experiments were carried out to evaluate the toxicity of aqueous plant extracts and their green synthesized silver nanoparticles compared with mineral oil, Beauveria bassiana, and chlorpyrifos on P. hypostoma. The result showed that chlorpyrifos was the most toxic compound, whereas black peper aqueous extract was the least toxic one, however, B. bassiana, K. Z. oil, Garlic aqueous extract, Chili pepper AgNPs, turmeric aqueous extract, Turmeric AgNPs, Garlic AgNPs, Black peper AgNPs, and Chili pepper aqueous extract lie in between. Conclusively, based on those results all selected compounds and extracts caused significant mortality for workers of P. hypostoma as compared to control and can be used as a cheap and effective alternative in future IPM programs against P. hypostoma.