The ability of the animal gut to absorb the trace elements and other nutrients, therefore, improving the growth performance of animals. Nanoparticles of Selenium (Nano-Se) promote growth performance of rabbits and it can act as antioxidants, antibacterial agents, improving the immunity system of the rabbits. Moreover, Se is one of the critical nutritional factors necessary for the normal functioning of the immune system and maintenance of gut health, growth, and organ functions. Numerous studies have demonstrated that a deficiency in Se could lead to serious disruptions in animal performances such as growth, digestion, liver damage, pancreatic fibrosis, cystic ovaries, and thyroid metabolism dysfunction. Furthermore, sufficient Se supplementation in rabbits tends to maintain good health and productive performance. The levels of Se in the rabbit diets vary widely according to dietary ingredients and selenium supplementation, ranging from 0.05 to 2.0 mg/kg diet. Since there are almost unlimited possibilities concerning the dosage of Se there is still more research needed. This review gives an overview of the mode of action, recommendation levels of Nano-Se, and their effects on growth performance, nutrient digestibility, carcass criteria and blood biochemical of rabbits.