Objective: The aim of this study was to assess apical root resorption (RR) following the application of micro-osteoperforation (MOP) and piezocision (PzC) assisted orthodontics for acceleration of tooth movement (TM). Materials and Methods: A total number of 16 patients seeking orthodontic therapy were included in this study. All patients undergone 1st premolars extraction and were indicated for canine retraction afterwards. These patients were divided into 2 groups; group A was treated using MOP in one side and the other side serves as control. While in group B PzC was performed in one side and no intervention was done to the other side. CBCT scans were taken for every patient before and after canine retraction in order to evaluate amount of RR in both groups. Results: In MOP group, there was no significant difference in canine root length between experimental and control sides. Whereas, in PzC group, there was statistically significant decrease in root length in experimental side than the control side. When comparing both groups, experimental PzC side showed statistically significant decrease in root length compared to experimental MOP side postoperatively. Conclusion: Experimental PzC showed statistically significant decrease in canine root length compared to experimental MOP and control side after canine retraction.