The main concern of the present study was to examine the effectiveness of developing a translation course based on the strategic self-regulated learning in improving EFL majors' translation competence. Adopting quasi-experimental design, the participants, consisting of 60 EFL majors at the Faculty of Foreign Languages and Translation, Misr University for Science and Technology, were randomly selected and distributed equally to two groups, the experimental group and the control group. To fulfill the purpose of the study, a translation competence test was constructed and validated. Results revealed the effectiveness of the developed course in improving translation competence of the experimental group students. The results also showed that the experimental group students outperformed the control group on the posttest translation competence test. It is recommended that self-regulation training should be accorded adequate attention in EFL curriculum in order to cater for independence and life-long learning that meet the demands of the 21^st century. The study also called for adopting competence-based orientation in designing translation courses through making available training workshops for EFL majors and giving prominence to selecting appropriate strategies particularly those emphasizing autonomy in the learning process.