This study aimed to investigate the effect of diets enriched with artichoke and green coffee seeds powders on hepatopathy rats. Twenty five adult male albino rats (Sprague Dawley strain), weighting (160±10g) used in this study and assigned to two main groups. The first is a negative control group (5 rats) was received a basal diet throughout the  experiment .The second group (20 rats) was injected s/c by (0.2ml/kg) carbon tetrachloride for two weeks, twice a week. The percent of plants seeds which were used 7% artichoke seeds, 7%green coffee seeds and 7%mix of them from the basal diet. Serum liver function (AST, ALT and ALP), (SOD, GPx and CAT), (total protein, albumin and globulin), ( total bilirubin, direct bilirubin and indirect bilirubin), total cholesterol and triglycerides, lipoproteins (VLDL-c, HDL-c, LDL-c) were determined, kidney function was also assessed (urea, creatinine, uric acid).The results revealed that, the control (+ve) group showed a significant increase in  (ALT, AST, ALP)c ompared with the control (-ve) 7% green coffee seeds powder was the best results, the results of (total  protein, albumin and globulin) showed a significant increase in negative control compared with the control (+ve) (7% mix of artichoke and green coffee seeds powder) was the best results, but the results of lipid profile, kidney function and (total bilirubin, direct bilirubin, indirect bilirubin) revealed that, the control (+ve) group showed a significant increase in its compared with the control (-ve) (7% mix of artichoke and green coffee seeds powder) was the best results of lipid profile and kidney function but (7% artichoke seeds powder) was the best results of (total bilirubin, direct bilirubin, indirect bilirubin), on the other hand the control (+ve) group showed a significant decrease in (SOD, GPx, CAT) compared with the control (-ve) (7% mix of artichoke seeds powder) was the best results.The obtained results concluded that feeding with artichoke and green coffee seeds powder improved, liver function, kidney function and lipid profile