The clinical relevance of osteoporosis depends on the increase of fracture rate.The fracture risk assessment tool (FRAX) is a widely used tool to calculate the risk of fracture. The FRAX tool integrates bone mineral density (BMD) at the femoral neck only to calculate the 10-year fracture risk estimate, neglecting spine and forearm BMD. Focusing on the potential association between thyroid dysfunction and osteoporosis in Egyptian women, Damietta community, the purpose of the present study was to assess fracture risk by applying the FRAX tool in pre- and postmenopausal women with thyroid dysfunction, utilizing BMD data from spine and forearm. The results revealed that FRAX-score was gradually increased by the age in hypo- and hyperthyroid women, although the mean fracture risk was higher in hyperthyroid women in each of the lumbar spine and the forearm. All FRAX values were less than 10%, indicating a low fracture risk in thyroid dysfunction. No significant differences have been observed when FRAX values calculated from BMD of different regions have been compared for the same age category. These results may indicate that BMD data from different regions can be recruited to calculate the corresponding FRAX values.