The present study was carried out to evaluate the effect of vaccination strategies to control vibriosis in farmed marine fish in Damietta governorate-Egypt. Two types of vaccines were papered including formalin-killed bacteria as well as heat killed whole cell bacterins as administrated by intraperitoneal injection sea bream fish. Fish immunized with formalin killed vaccine gave rise disease resistance better than heat killed vaccine in challenge test as denoted by relative level of protection (RLP). Determination of single immune diffusion, micro agglutination techniques and total protein content showed that formalin vaccine produce a good disease protection than the heat killed vaccine. Complete blood count examination for detecting lymphocytic count, hemoglobin %, RBCs count and WBCs count showd that formalin vaccine was the best. The booster dose after three months declared elevation of immune status of the fish. Highly significant effect was observed in hemoglobin  levels, circulating lymphocyte count and total protein content in fish immunized with formalin vaccine than heat killed vaccine