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239372

EFFECT OF EXTRACTION TIME ON THE BIOACTIVE COMPOUNDS OF BOTTLE GOURD (LAGENARIA SICERARIA) USING GAS CHROMATOGRAPHY-MASS SPECTROMETRY

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Last updated: 04 Jan 2025

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Abstract

Traditional medical systems have always been played an important role in meeting global healthcare needs. Meanwhile,bottle gourd (Lagenaria siceraria) is a vegetable that contains health-promoting secondary metabolites. Therefore,thisstudy aims to determine the bioactive compounds profiling of Bottle gourd (Lagenaria siceraria) fruit extracts in methanol and chloroform using gas chromatography-mass spectrometry (GC-MS) with variations in extraction time of 10, 20, and 30 min using GC-MS RTX-5 capillary column. A total of 91 compounds were tentatively identified, with 55 found in methanol and 41 in chloroform extract. The 1:2 (v/v) ratiousing methanol solvent at 30 min was suggested as the most suitable time for maximum extraction. Several peaks with high area percentages were discovered in the methanolic extract containing key chemical constituents such as stearic, oleic, palmitic, and linoleic acid, as well as Cholesta-4,6-dien-3-one, gamma sitosterol, and Phenol, 2,2'-methylene bis. Meanwhile,the corresponding constituents from chloroform extract include Tetracontane, Dotriacontane, Phenol, 2,2'-methylenebis, esters, and aromatic derivatives. Most of the bioactive compounds were detected between 20-30 min time of extraction. Moreover, fatty acids, methyl and ethyl esters, as well as sterols represent 40% of the total extracts and were dominated by oleic, and palmitic acid, gamma-sitosterol along with its ethyl and methyl esters. Therefore, methanol is recommended as the optimal solvent to obtain high content of phytochemical constituents and antioxidants for utilization in pharmacognosy.

DOI

10.21608/bfsa.2022.239372

Keywords

Bottle gourd, bioactive compounds, GC-MS, Ultra-sonication assisted extraction

Authors

First Name

Muhammad

Last Name

Yusuf

MiddleName

-

Affiliation

Department of Chemical Engineering, Politeknik Negeri Ujung Pandang, Makassar City, Indonesia

Email

yusufitri@poliupg.ac.id

City

-

Orcid

0000-0003-2503-9684

First Name

Sri

Last Name

Indriati

MiddleName

-

Affiliation

Department of Chemical Engineering, Politeknik Negeri Ujung Pandang, Makassar City, Indonesia

Email

indriati.sri59@gmail.com

City

-

Orcid

-

First Name

Nur

Last Name

Attahmid

MiddleName

Fitriani Usdyana

Affiliation

Department of Agroindustry, Politeknik Pertanian Negeri Pangkep, Pangkep Regency, Indonesia

Email

-

City

-

Orcid

-

First Name

Rahmawati

Last Name

Saleh

MiddleName

-

Affiliation

Department of Agroindustry, Politeknik Pertanian Negeri Pangkep, Pangkep Regency, Indonesia

Email

rahmawatisaleh12@yahoo.co.id

City

-

Orcid

-

First Name

Akhmad

Last Name

Rifai

MiddleName

-

Affiliation

Department of Chemical Engineering, Politeknik Negeri Ujung Pandang, Makassar City, Indonesia

Email

arrifai82@gmail.com

City

-

Orcid

0000-0002-6311-9039

Volume

45

Article Issue

1

Related Issue

34403

Issue Date

2022-06-01

Receive Date

2021-12-04

Publish Date

2022-06-01

Page Start

139

Page End

151

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 45_Issue 1_Pages 139-151.pdf

PDF . 888.0kB

Link

https://bpsa.journals.ekb.eg/article_239372.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=239372

Order

12

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

EFFECT OF EXTRACTION TIME ON THE BIOACTIVE COMPOUNDS OF BOTTLE GOURD (LAGENARIA SICERARIA) USING GAS CHROMATOGRAPHY-MASS SPECTROMETRY

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Article

Created At

22 Jan 2023