Present work was aimed to develop a liquid in-situ raft forming floating gastroretentive
system of repaglinide using gellan gum, pectin, and sodium alginate. The formulations were
characterized in terms of compatibility of drug-excipient by Fourier transform infrared, drug
content, effect of processing parameters on physical form of drug (crystalline or amorphous) by
X-ray diffraction analysis, thermal behaviour by differential scanning calorimetry, and in-vitro
drug release study. The results confirm no interaction between the drug-excipients and fusion of
drug crystals within the polymer matrix in amorphous form. The gel raft-floated for more than
24 hrs.. All the formulations showed instantaneous gelation within 30 seconds in 0.1 N HCl (pH
1.2). Formulation containing gellan gum (500 mg), pectin (500 mg), and glycerol monostearate
(500 mg) released 21% of the drug in first 4 hrs., 69% in 6 hrs. and reached 97% in 7 hrs.
Without gellan gum, 35% of the drug was released in the first 2 hrs. and reached 90% in 4 hrs.
Based on these results it is suggested that the incorporation of drug into the liquid in-situ raft
forming floating system may be an appropriate strategy to improve the dissolution profile of
poorly soluble drugs.