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110154

EFFECT OF GARLIC AND ATORVASTATIN ON LEPTIN AND LIPID PROFILE IN TRITON X-100 INDUCED HYPERLIPIDEMIA IN RATS

Article

Last updated: 25 Dec 2024

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Subjects

-

Tags

Veterinary Anatomy, Histology and Physiology “Veterinary Academic Studies".

Abstract

Hyperlipidemia is widely known to be the major risk factor for the development of cardiovascular diseases. This study was conducted to determine the effect of Garlic on  Leptin hormone and Lipid Profile in Triton x-100 induced hyperlipidemic rats compared with standard hypolipidemic Atorvastatin. A total number of 60 albino rats were allocated into six equal groups, 10 rats each. The first group was kept on Standard pellet diet (served as normal control), the second group was kept on 1% garlic added to standard pellet diet, the third group was administered with standard Atorvastatin 10 mg/kg p.o. daily (served as standard), the forth group was given a single dose of triton at a dose 100 mg/kg and repeated every two weeks, i.p. (served as Triton control), fifth and sixth groups were given a single dose of triton at a dose 100 mg/kg and repeated every two weeks, i.p. and the fifth group was given garlic 1% added to standard pellet diet while sixth group was administered with standard Atorvastatin 10 mg/kg p.o. (served as treated groups), after inducing hyperlipidemia (for 6 weeks). Results showed that, garlic significantly decreased cholesterol, LDL-C, VLDL-C and TG and significantly increased HDL compared with triton x-100 -treated group. On the other hand, there were a non significant differences in total lipid, phospholipids and leptin levels compared with triton x-100 -treated group. We concluded that, Garlic has definite antihyperlipidemic activity in Triton X-100 induced hyperlipidemia model which is equipotent activity when compared with Atorvastatin. This might returned in addition to its own hypolipidemc activity to increased leptin sensitivity in hypothalamus. Further studies on Garlic needed to identify the possible mechanism of action on leptin hormone.

DOI

10.21608/kvmj.2014.110154

Keywords

Atorvastatin, Garlic, hyperlipidemia, leptin, Triton X-100

Authors

First Name

Nabil M.

Last Name

Taha

MiddleName

-

Affiliation

Department of Biochemistry, Faculty of Veterinary Medicine, Alexandria University, Egypt.

Email

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City

-

Orcid

-

First Name

Hatem S.

Last Name

Abdel-Hamid

MiddleName

-

Affiliation

Department of poultry diseases, Faculty of Veterinary Medicine, Damanhur University, Egypt.

Email

-

City

-

Orcid

-

First Name

Kadry M.

Last Name

Sadek

MiddleName

-

Affiliation

Department of Biochemistry, Faculty of Veterinary Medicine, Damanhur University, Egypt.

Email

-

City

-

Orcid

-

First Name

Ahmed Z.

Last Name

Abdalaziz

MiddleName

-

Affiliation

Department of Biochemistry, Faculty of Veterinary Medicine, Damanhur University, Egypt.

Email

-

City

-

Orcid

-

Volume

12

Article Issue

2

Related Issue

16455

Issue Date

2014-10-01

Receive Date

2014-07-01

Publish Date

2014-10-01

Page Start

109

Page End

127

Print ISSN

1687-1456

Online ISSN

2682-2954

Article File

KVMJ_Volume 12_Issue 2_Pages 109-127.pdf

PDF . 613.3kB

Link

https://kvmj.journals.ekb.eg/article_110154.html

Detail API

https://kvmj.journals.ekb.eg/service?article_code=110154

Order

7

Type

Original Article

Type Code

1,064

Publication Type

Journal

Publication Title

Kafrelsheikh Veterinary Medical Journal

Publication Link

https://kvmj.journals.ekb.eg/

MainTitle

EFFECT OF GARLIC AND ATORVASTATIN ON LEPTIN AND LIPID PROFILE IN TRITON X-100 INDUCED HYPERLIPIDEMIA IN RATS

Details

Type

Article

Created At

22 Jan 2023