An important and target aspect of the fiber-to-yarn prOduction process is the quality and price of the resulting yarn. The yarn should have optimal product characteristics, while maintaining as low a price as possible. To meet this target, Giza 85 Egyptian cotton variety, was chosen and blended with Sudanese Upland cotton (Acala) and also, with Greek Upland cotton. Ten different combinations of blend levels including the 100 % fiber types were performed for two different spinning systems, open-end yam counts of 25 Ne and 35 Ne and also, 30 Ne and 40Ne for ring spinning, at constant twist multiplier 4.0. Giza 85, Egyptian cotton variety is of higher quality than the two upland cotton varieties especially in fiber strength, length uniformity, fiber fineness, and elongation while of low spinning waste. The addition of different ratios of Giza 85 cotton fiber improved the mechanical properties of the Greek and Sudanese cotton yarns. The Uster provisional 5%, 25% and 50% yarn strength quality levels were suggested for using the Egyptian/Greek or Sudanese cotton blending, in order to achieve optimum yarn quality properties and to reduce and control the raw material cost. The spinner's cost could be reduced by trying different combinations of cotton qualities until matching the one that still allows for the required yarn properties is found.