The present work deals with 9 different trials as vaccination programmes against egg drop syndrome (EDS) using three locally prepared vaccine formulae induding cell allure, live attenuated and inactivated vaccines (prepared on chicken embryo fibroblasts), and inactivated duck egg vaccine. The applied programmes indude vaccination of young chicks at 4 weeks of age and older ones at 19 weeks of age prior to the start of egg production. Also, these programmes include vaccination of such birds with one and two doses. Evaluation of the applied vaccination programmes was depending on the estimation of spedfic induced EDS antibodies using serum neutralization test (SNT) and Haemagglutination test (HI), in addition to the egg production curve. All vaccinated thickens .were still healthy allover the experimental period showing no abnormal signs ,confirming safety of the vaccine, and were able to withstand the challenge virus , while, unvaccinated birds did not withstand it. The obtained results revealed that the best vaccination programme Is that which included vaccination of thickens at 4 weeks and then revaccinated at 19 weeks of age before starting of the season of egg production (programmes 4,5&6 "VP4, VPS & VP6) and resulted in the highest levels of antibodies and egg production