Present work was carried out at Zagazig district, Sharkia Governorate during 2008and2009seasons to evaluate the effect of some bioinsecticides, Jojoba oil, Dimilin and Dursban on Spodoptera littoralis and some accompanied Predators under field condition. The results indicated that the initial effect of the tested compounds, (expressed as the rate of reduction in the percent infestation) recorded (18.7, 23.61, 23.6, and 17.9% in the first season. (2008), (16.88, 19.53, 19.9 and 17% in the second one (2009) for Biorinza, Biovar, Protecto and Jojoba oil, respectively. It is obvious that Biovar was the most potent compound in both seasons. Also, results indicate that the initial effect of tested IGR (Dimilin) induced reduction in the rate of S. littoralis infestation, as it recorded (77.295%) reduction, in 2008 season, 71.8% during 2009. Dursban recorded 95% in 2008 season: 94.09% during 2009. bioinsecticides and Jojoba oil recorded on predators (13.7, 14.97, 12.43 and 19% in the first season 2008, 10.41, 13.19, 9.74 and 15.85 % in the second one 2009 for Biorinza, Biovar, Protecto and Jojoba oil, respectively. Dimilin recorded after five days 18.61% in the first season 2008, 16.70 % during 2009.The initial effect of Dursban on predators reduction was 89.42% in first season, 83.26% second season. Dursban was the highest effective compound against predators . The higher toxicity of Dursban could be attributed to its toxic effect against nearly all the developmental stages of predators.