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150287

PREPARATION AND EVALUATION OF ADJUVANTED LIVE VACCINE AGAINST INFECTIOUS BRONCHITIS

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Last updated: 24 Dec 2024

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Abstract

live vaccines are widely used in poultry industry. Such vaccines can be either injected or delivered onto the bird mucosa and most probably not adjuvanted. The herein study was devoted to focus on the potential role of gel adjuvant when added to infectious bronchitis live attenuated vaccine (IB). Montanide gel 01 is a polymer adjuvant that was recommended to be added to live vaccines improving their immunogenicity and efficacy. It was noted that augmentation of IB live vaccine with Montanide gel 01 resulted in superior quality vaccine when utilized as spray as well as the intranasal methods. Both humoral and cellular immunity were higher upon using the IB- Montanide gel 01 more than the conventional non- adjuvanted IB vaccines. Moreover, the gel 01 IB vaccine showed higher protection than the ordinary vaccines when challenged with the virulent IB strains. It was also demonstrated that gel IB vaccine could be successfully used as spray and intranasal delivered vaccine especially in mass vaccination in huge poultry industry. The results also proved that the use of Montanide gel 01 vaccine increased the safety margin of the IB vaccine and enhanced the IB vaccine efficacy.

DOI

10.21608/ejar.2017.150287

Keywords

Live Vaccine, Infectious Bronchitis, Adjuvant, Mucosal Delivery, Montanide

Authors

First Name

SAMAH A.

Last Name

ABODALAL

MiddleName

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Affiliation

Veterinary Serum and Vaccine Research Institute Abbasia, Cairo, Egypt, P. O. B. 131

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Orcid

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Volume

95

Article Issue

3

Related Issue

21933

Issue Date

2017-09-01

Receive Date

2017-05-16

Publish Date

2017-09-01

Page Start

1,327

Page End

1,337

Print ISSN

1110-6336

Online ISSN

2812-4936

Link

https://ejar.journals.ekb.eg/article_150287.html

Detail API

https://ejar.journals.ekb.eg/service?article_code=150287

Order

22

Type

Original Article

Type Code

1,041

Publication Type

Journal

Publication Title

Egyptian Journal of Agricultural Research

Publication Link

https://ejar.journals.ekb.eg/

MainTitle

PREPARATION AND EVALUATION OF ADJUVANTED LIVE VACCINE AGAINST INFECTIOUS BRONCHITIS

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Article

Created At

22 Jan 2023