The objectives of the current study were first to investigate the prevalence rates of Salmonella spp. in the buffalo meat and edible offal (round, masseter muscles, liver, kidney, and trimmings) retailed in Zagazig city, Egypt. Second, serological identification of the isolated Salmonella spp., was followed. Third, screening of antimicrobial sensitivity testing of the identified Salmonella Typhimurium was done using the disk diffusion assay. Finally, the inhibitory effects of rosemary and olive oils against Salmonella Typhimurium were investigated. The obtained results in the present study revealed isolation of Salmonella spp., from the examined round, masseter muscles, liver, kidney, and trimmings at 15%, 25%, 35%, 25%, and 50%, respectively. Serological identification of Salmonella spp. revealed recovery of six serotypes namely, S. Typhimurium, S. Enteritidis, S. Kentucky, S. Inganda, S. Apeyeme, and S. Anatum from the examined samples at variable rates. The overall isolation rates of these serotypes were 26.64%, 29.97%, 16.65%, 9.99% 9.99%, and 6.66%, respectively. Salmonella Typhimurium isolates had clear multidrug resistance profiles. Rosemary and olive oils at 0.1%, and 0.5% could significantly reduce S. Typhimurium in an experimental trial in a concentration-dependent phenomenon.