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281483

Toxicological Studies on the Sinai Plant Urginea maritima (Scilla) in Wistar Albino Rats

Article

Last updated: 24 Dec 2024

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Subjects

-

Tags

Forensic Medicine and Toxicology

Abstract

The varied toxicity of Urginea maritima (a plant that grows in north Sinai) on Wistar albino rats was investigated. Twenty-four rats weighing 100±20 gm. were divided into 4 groups, the first group, which included six male rats, and the second group, which included six female rats, were given di-methyl sulfoxide orally for 45 consecutive days and were regarded as the control groups. The third group included six male rats who received 36 mg/kg B.W (1/20 LD50 from the alcoholic extract of Urginea maritima) for 45 days in succession. The fourth group was made up of six female rats who received a daily dose of 26 mg/kg B.W (1/20 LD50 of the alcoholic Urginea maritima extract) for 45 successive days. Serum samples were taken for biochemical study after the end of the experiment, and sciatic nerve, heart, and brain tissues were also taken for histopathological analysis. The findings demonstrated significant changes in the exposed animals' serum levels of calcium (Ca++), sodium (Na+), and potassium (K+) ions. While serum K+ levels dramatically increased, serum Ca++ and Na+ levels significantly dropped. Lactic acid dehydrogenase (LDH) and serum creatine kinase (CK-MB) activities also significantly increased. In addition, pathological alterations in the heart, brain, and sciatic nerve were discovered when compared to control groups.

DOI

10.21608/scvmj.2022.281483

Keywords

Urginea maritima, CK-MB, LDH, ions, LD50, cardiotoxicity

Authors

First Name

Jaklin

Last Name

Merzek

MiddleName

L.

Affiliation

Veterinary Medicine directorate, North Sinai

Email

-

City

-

Orcid

-

First Name

Shereen

Last Name

Mahmoud

MiddleName

M.

Affiliation

Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, Egypt

Email

rinamoh2002@hotmail.com

City

-

Orcid

0000-0002-9654-8980

First Name

Ayman

Last Name

Abdel-Hamid

MiddleName

K.

Affiliation

Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, Egypt,

Email

-

City

-

Orcid

-

First Name

Kawther

Last Name

Alhady

MiddleName

A.

Affiliation

Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, Egypt

Email

-

City

-

Orcid

-

First Name

Rania

Last Name

Abdou

MiddleName

H.

Affiliation

Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, Egypt

Email

-

City

-

Orcid

-

Volume

27

Article Issue

2

Related Issue

37880

Issue Date

2022-12-01

Receive Date

2022-08-25

Publish Date

2022-12-31

Page Start

333

Page End

351

Print ISSN

1110-6298

Online ISSN

2682-3284

Article File

SCVMJ_Volume 27_Issue 2_Pages 333-351.pdf

PDF . 1.4MB

Link

https://scvmj.journals.ekb.eg/article_281483.html

Detail API

https://scvmj.journals.ekb.eg/service?article_code=281483

Order

11

Type

Original Article

Type Code

992

Publication Type

Journal

Publication Title

Suez Canal Veterinary Medical Journal. SCVMJ

Publication Link

https://scvmj.journals.ekb.eg/

MainTitle

Toxicological Studies on the Sinai Plant Urginea maritima (Scilla) in Wistar Albino Rats

Details

Type

Article

Created At

22 Jan 2023