S. aureus which causes food poisoning, suppurative lesions and mastitis is one of the most serious bacteria causing community acquired infection.  A total of 191 random samples were collected as follow 52 samples from raw meat, 51 samples from raw milk, 45 samples from poultry and 43 samples from lesion swabs (abscess, wounds and sputum of animals) for isolation of S. aureus and detection of its sensitivity to various antimicrobial drugs. One sample of raw meat was positive for S. aureus, two samples of raw milk one of them was from mastitis case were positive for S. aureus, sputum sample from dog with respiratory manifestation was positive for S. aureus, abscess sample from ear of cat was positive for S. aureus, with total of five S. aureus isolates (9.5%). All this isolate was positive to slide coagulase test.  According to antimicrobial resistance patterns, S. aureus isolates were extremely resistant to tetracycline, ciprofloxin, erythromycin, cefoxitin, norfloxacin, Penicillin G, oxacillin, but very sensitive to Sulphmethoxazole trimethoprim, rifampicin, chloramphenicol, moxifloxacin, gentamicin, ofloxacin, vancomycin, clindamycin