The present work was performed to study the protective and curative anti-inflammatory role of natural moringa and licorice extract as anti-inflammatory agents on carrageenan-induced paw edema in rats. Seventy-two male albino rats (weighing 100-120 g) were divided into the following 6 groups; Control group (C): Kept as normal control that received normal saline 0.9% NaCl solution in a dose of 0.5 ml/kg body weight for 10 days, Moringa group (MO): Normal rats that received daily MO oil extract in a dose of 400 mg/kg body weight orally for 10 days , Licorice Group (L): Normal rats that received daily L extract in a dose of 250 mg/kg body weight orally for 10 days, Control arthritic group (CA): Normal rats received normal saline 0.9% NaCl solution in a dose of 0.5 ml/kg body weight for 10 days then a single injection of 0.1 ml of carrageenan-saline solution (1%, w/v) into the plantar surface of the hind paw of left leg at the 10th day of the experiment, Moringa arthritic group (MA): Normal rats that received daily MO oil extract in a dose of 400mg/kg body weight orally for 10 days then received a single injection of 0.1 ml of carrageenan-saline solution (1%, w/v) into the plantar surface of the hind paw of left leg at the 10th day of the experiment, Licorice arthritic group (LA): Normal rats that received daily L extract in a dose of 250mg/kg body weight orally for 10 days with modification of route of administration then received a single injection of 0.1 ml of carrageenan-saline solution (1%, w/v) into the plantar surface of the hind paw of left leg at the 10th day of the experiment. The results showed significant increase in paw edema volume in CA group was more pronounced after five hours. On the other hand, MA and LA groups showed an improvement in the edema volume comparing with the CA group. MA and LA groups significantly ameliorated the levels of serum hepatic, antioxidant and cytokines that deteriorated by carrageenan. Histopathological examination of hind paws was in concurrence with the biochemical results. It is logical to consider that the anti-inflammatory, antioxidative properties of MO and L are mechanistically achieved. So, MO and L could be used as protective agents against inflammation.