Autoimmune diseases (AD) result from the breakdown of self-tolerance where the immune system attacks self-antigens leading to multiple organ failure. It affects animals and humans. Genetic predisposition and environmental factors influence the development of AD. For understanding disease pathogenesis and developing immunotherapeutic strategies, several animal models have been developed. Spontaneous and induced animal models of autoimmune diseases were used. The Induced autoimmune models involved the use of experimental infections, drugs, chemicals, metals, and environmental substances. Among the environmental substances that raise a concern and act as a potential candidate for use in an autoimmune animal model is silica. Nowadays, the use of natural compounds is gaining wide popularity since it's a safer and cheaper source of drugs. The relation between silica and autoimmune disease is discussed in this review. Furthermore, various treatment options are reviewed which include available medications and possible natural anti-inflammatory compounds. Myrrh as a natural medicine possessing anti-inflammatory properties makes it a possible conjunctive treatment to autoimmune diseases.