This study was conducted to investigate the curative effect of cefquinome against Aeromonas hydrophila in Nile tilapia and the effect of hematological and histopathological findings. One hundred and thirty-five Nile tilapia fish were used and divided into 3 equal groups. 1^st group (GP) served as a negative control, 2^nd GP was positive and infected with A. hydrophila while 3^rd GP was infected group and treated with Cefquinome. The clinical signs improved in 3^rd GP compared to 2^nd GP and the mortality was decreased from 66.6 % in 2^nd GP to 17.7 % in 3^rd GP. Cefquinome treatment showed an improvement in all hematological parameters and histopathological findings of experimentally infected Nile tilapia in a time-dependent manner. It could be concluded that cefquinome is effective in treatment Nile tilapia fish against Aeromonas hydrophila infectioin with marked improvement in the health status and histopathological as well as hematological findings.