The research aim to examine the relation between transformational leadership and strategic challenges in pharma corporations in Egypt . the research problem that there are a shortage in applying the concepts of leadership in pharma companies in Egypt specially transformational leadership and its role in facing the strategic challenges . the population is all employees in Ibn Sina, Maphis, Cairo, Glasco and Nile and it were 20679 items and the sample is 377 items . the methodology used is multiple regression to examine the relation between the four dimensions of transformational leadership and strategic challenges . the findings are that there is a significant relation between the four dimensions of transformational leadership and strategic challenges .