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270509

Mean Platelet Volume in Psoriasis: Is it a New Prognostic Indicator?

Article

Last updated: 04 Jan 2025

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Subjects

-

Tags

Clinical Research (Medical)

Abstract

Background: Psoriasis is a chronic multifactorial inflammatory autoimmune disease. It has significant impacts on health and quality of life. Platelets play a major role in the pathogenesis of psoriasis, and the activated platelets increase the migration of leukocytes to the skin, increasing the release of inflammatory cytokines. Recent studies showed that MPV (mean platelet volume) could be used as an indicator of platelet function and activation. Previous studies assessed only the value of MPV in psoriatic patients without studying its relationrelationship < /ins> with different treatment modalities. Aim:To study the changes in MPV in psoriasis patients and its association with disease severity after treatment with NB-UVB. Patents and Methods: 25 psoriatic patients were assessed for MPV and psoriasis area and severity index score (PASI) before treatment, during treatment and after treatment with NBUVB (three times weekly for 3 months). Results:The relation between MPV and PASI was statistically insignificant before and after treatment. The PASI score was significantly decreases after treatment. Conclusion: This study demonstrated insignificant correlation between MPV levels and PASI score of psoriatic patients before and after NBUVB phototherapy. Further studies on larger number of patients were needed to assess the relation between MPV and psoriasis.
 

DOI

10.21608/scumj.2022.270509

Keywords

Psoriasis, Mean platelet volume, NB-UVB

Authors

First Name

Noha

Last Name

Tawfik

MiddleName

-

Affiliation

Department of Dermatology, Venereology, and Andrology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.

Email

nohazakaria1@gmail.com

City

-

Orcid

0000-0002-0687-4775

First Name

Samar

Last Name

Romeia

MiddleName

GA

Affiliation

Department of Dermatology, Venereology, and Andrology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.

Email

-

City

-

Orcid

-

First Name

Nahed

Last Name

Youssef

MiddleName

-

Affiliation

Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt

Email

-

City

-

Orcid

-

First Name

Mona

Last Name

Atwa

MiddleName

A.

Affiliation

Department of Dermatology, Venereology, and Andrology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.

Email

atwamona@gmail.com

City

-

Orcid

-

Volume

25

Article Issue

4

Related Issue

37696

Issue Date

2022-12-01

Receive Date

2022-11-20

Publish Date

2022-12-01

Page Start

54

Page End

60

Print ISSN

1110-6999

Online ISSN

2090-2581

Article File

SCUMJ_Volume 25_Issue 4_Pages 54-60.pdf

PDF . 359.2kB

Link

https://scumj.journals.ekb.eg/article_270509.html

Detail API

https://scumj.journals.ekb.eg/service?article_code=270509

Order

7

Type

Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

MainTitle

Mean Platelet Volume in Psoriasis: Is it a New Prognostic Indicator?

Details

Type

Article

Created At

22 Jan 2023