The conducted experiment aimed to study the effect of NPK Nano-fertilizers applied at similar or less rates that could replace the recommended levels of NPK conventional fertilizers without having a negative impact on plant growth, yield, nutritional content, plant growth, crop yield and nutrient content. A complete randomized pot experiment in the three replicates was carried out in green house of Soils and water Department, Faculty of agriculture, Al -Azhar University (Nasr City, Cairo, Egypt), during the winter  season of 2019. Nano fertilizers have been added at rates of (15%, 25% ,50 % and 75%) of recommended doses from N, P and K and their interactions compared to chemical fertilizers on the growth, crop yield and nutrient uptake of faba bean (Vicia faba L.) planting in sandy loam soil. There are (8) fertilization treatments in this study: single Nano N, P, K, di-combination Nano (N+P), (N+K), (P+K), tri-Nano (N+P+K), and control treatment. six faba bean seeds were planted in each pot. Results showed that the application of NPK Nano-fertilizers at under rates of recommended levels (NPK) of Chemical fertilizers (traditional fertilizers). led to increase in dry weight, crop yield, and nutrient uptake. In this regard, the most suitable treatment was 25% (NPK) Nano fertilizers from RD., which gave the highest values of all the aforementioned traits.