This study aimed at the development of brain –based strategy on the reading fluency skills among third year preparatory students. 32 third year preparatory students at EL-Shaheed Abd Allah Mohamed Abd Allah Preparatory School, Zagazig, El Sharkia Governorate, served as a experimental group, and 30 third year preparatory students at Sharweda Preparatory School, Zagazig, El Sharkia Governorate, served as a control group. The experimental group was taught using brain- based strategy. The control group was tough using the traditional method. A reading fluency test that tests reading rate, accuracy and prosody was administered to the students in the two groups as pre-posttests. In addition, a rubric for assessing prosody was used. The proposed program was taught over a period of 3 months (five periods per week).  The results of the study showed that the experimental group students outperformed the control group students in reading fluency skills.