The purpose of this study was to evaluate the impacts of two Lactic Acid Bacteria strains (LAB) Pediococcus acidilactici (P. acidilactici) and Lactococcus Lactis (L. Lactis)) isolated from fermented dairy products. In this study, 24 female rats were divided into three groups (8 rats per each group): (1) untreated group, (2) P. acidilactici group: rats fed orally with 108 CFU /ml skim milk, (3) L. Lactis group: rats fed orally with 108 CFU /ml skim milk for 6 weeks. Bodyweight gain, daily feed intake, relative weight organs, hematological parameters, ALT, AST, protein, albumin, globulin, urea, creatinine, and histopathological examinations of liver and kidney were determined at the end of the experiment. Results: In this analysis, statistical significance was found for certain parameters e.g. organ weights, hematology, and clinical chemistry; none of these improvements were expected due to the treatment since the changes remained close to controls, also, histological studies of the liver and kidney observed no and mild morphology changes in the liver or kidney. The current study indicates that administration of P. acidilactici and L. Lactis strains of LAB didn't harm laboratory rats and safe for animal or human consumption.