The current work aims to evaluate the yield of sweet potato clones which suitable for human and animal feeding and compare it with local cultivar, in addition to determine the antioxidant activity and active ingredients in different sweet potato cultivar. Two years of field trials 2018 and 2019 were achieved at the Research Farm, Sids Horticulture Research Station, ARC. Twenty-six property (8 vegetative criteria) and 18 chemical constituents were evaluated. Dark orange-fleshed Beauregard recorded the highest values for many vegetative properties and chemical constituents such as the number of branches/plant, total marketable yield (kg/plot), total yield, total starch, inulin, and secondary metabolites. From the results, it can use Beauregard, Abees, SP1 and SP4 as a source of phenolic compounds and total flavonoids (TPCs conc. 25.75 – 122.17 mg/g in skin extract, 25.42 – 52.33 mg/g in flesh extract and TFs conc. 8.33 – 106.15 µg/g in skin extract, 6.22 – 61.81 µg/g in flesh extract) among the various sweet potato sample extracts. The order of antioxidant activity of the clone extracts was found to be in the skin extract as follows, Beauregard > Sp1 > Sp2 and in the flesh extracts as follows, Beauregard > Abees at high concentration of extract (50 μg/ml) However, Beauregard skin extract showed the highest FRAP (Ferric Reducing Antioxidant Potential) value (922.43 µM trolox/100 g dry weight) and (748.43 µM trolox/100 g dry weight) in the flesh extract. The Beauregard extract possesses a significant free radical scavenging ability (20.78%) compare to the standard trolox (95.5%).