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57524

Effect of glutathione on antimicrobial activity of levofloxacin

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Last updated: 04 Jan 2025

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Abstract

Overuse of antibiotics has become the major factor for the emergence anddissemination of multi-drug resistant strains of several groups of microorganisms andthis lead to search for agents that may be asolution,Fluoroquinolones are a group of antibiotics widelyused because of their broad spectrum activity against both Gram-positive  and Gram-negative bacteria.  In this study We report the effect of glutathione on the antibacterial action of levofloxacin on E-coli and S. aureus aslevofloxacin  is an important and commonly used members of the fluoroquinolonesantibiotics.Itinhibit DNA topoisomerase II and DNA topoisomerase IV activities, eventually leading tobacterial cell death. In addition, an increase of reactive oxygen species in the bacterial cells in response to levofloxacin has been shown.

DOI

10.21608/rjab.2018.57524

Keywords

Fluoroquinolones, side effects, microbial activity and antioxidants

Authors

First Name

Amal

Last Name

AbdEl-Aziz

MiddleName

A.

Affiliation

Molecular Biology Department, Genetic Engineering and Biotechnology Research Institute (GEBRI), University of Sadat City, Sadat city, Egypt

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Orcid

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First Name

Wafaa

Last Name

Zahran

MiddleName

A.

Affiliation

Microbiology and Immunology Department, faculty of Medicine, Menofiya University, Menofiya, Egypt

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Orcid

-

First Name

Hoda

Last Name

Mahrous

MiddleName

-

Affiliation

Industerial Biotechnology Department, Genetic Engineering and Biotechnology Research Institute (GEBRI), University of Sadat City, Sadat city, Egypt

Email

hmahrous7@yahoo.com

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Orcid

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First Name

Hany

Last Name

Khalil

MiddleName

-

Affiliation

Molecular Biology Department, Genetic Engineering and Biotechnology Research Institute (GEBRI), University of Sadat City, Sadat city, Egypt

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-

Orcid

-

First Name

Amira

Last Name

El-Khayat

MiddleName

H.

Affiliation

Microbiology and Immunology Department, faculty of Medicine, Menofiya University, Menofiya, Egypt

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-

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-

Orcid

-

First Name

Saadiya

Last Name

El-Nahas

MiddleName

A.

Affiliation

Molecular Biology Department, Genetic Engineering and Biotechnology Research Institute (GEBRI), University of Sadat City, Sadat city, Egypt

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Volume

4

Article Issue

1

Related Issue

8741

Issue Date

2018-06-01

Receive Date

2019-11-07

Publish Date

2018-06-01

Page Start

82

Page End

86

Print ISSN

2356-9433

Online ISSN

2682-3470

Article File

RJAB_Volume 4_Issue 1_Pages 82-86.pdf

PDF . 678.3kB

Link

https://rjab.journals.ekb.eg/article_57524.html

Detail API

https://rjab.journals.ekb.eg/service?article_code=57524

Order

7

Type

Original Article

Type Code

890

Publication Type

Journal

Publication Title

Research Journal of Applied Biotechnology

Publication Link

https://rjab.journals.ekb.eg/

MainTitle

Effect of glutathione on antimicrobial activity of levofloxacin

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Article

Created At

22 Jan 2023