The present study was conducted to evaluate the effect of green tea on albino rats for a long period (120 days), and the interaction between the green tea supplementation in the presence of ADI dose of pesticide toxicity induced from Profenofos pesticide. To achieve this, 48 male albino rats with similar weights and ages were used in the present study, and were divided into four groups as follows: first group used as control (non treated); second group (treated with aqueous green tea extract GTE); third group treated with pesticide (ADI dose) and fourth group treated with both GTE and ADI dose of pesticide. Data obtained revealed that green tea supplementation have a positive potential effect against pesticide toxicity. Nevertheless, it improves the biochemical plasma parameters either alone or combined with pesticide.