Bacterial spot caused by Xanthomonas campestris pv. vesicatoria is an important bacterial diseases of pepper and tomato. The present work was planned to record the disease incidence under protected agriculture and open field conditions in different localities of Nile Delta. Also to study the relationship between environmental factors (average daily temperature and relative humidity) and disease severity. The results showed that the open fields were free from the disease during the growing seasons of 2007-2009. Under the protected agriculture conditions, the disease was shown in all surveyed localities. The highest disease severity was recorded in El-Khatatba, El-Fayoum and El-Salhia regions, while it was moderately shown at El-Bosaily; Gazera-El-Dhab, Kha and El-Giza region. However, the disease severity on pepper increased with increasing the average of daily temperature and relative humidity. The disease was sever in the growing seasons 2007-2008 and less in 2008-2009 seasons and this phenomena probably due to the change in the climate between the two different seasons.