Experiments were conducted to study the α-tocopherol and ascorbic acid on modify the leaf senescence process of wheat grown under three salinity levels (0.8, 7.5, and 11.5 dSm^-1). The parameters analyzed were soluble protein content, chlorophyll content, electrolyte permeability, ions content, lipid peroxidation, hydrogen peroxide content, catalase and peroxidase activities, ascorbic acid content, phenol, and total carotenoids contents. Salinity hastened the naturally-occurring senescence rate of wheat flag leaves, it decreased concentrations of chlorophyll, total carotenoids, ascorbic acid, total phenol, calcium, potassium, magnesium, K⁺/Na⁺ ratio and soluble protein contents as well as the activities of Catalase and peroxidase. On the other hand, it increased sodium and chloride and chlorophyll_a:b ratio as well as membrane permeability, hydrogen peroxide content and malondialdehyde content. Spraying with both antioxidants reduced the hydrogen peroxide accumulation, lipid peroxidation, membrane permeability, sodium and chloride content, whereas the antioxidants enzyme activities (catalase, and peroxidase) were increased. Enhanced accumulation of ascorbate, phenol, carotenoids, calcium, potassium and magnesium was recorded in antioxidants-sprayed plants at 65 days after sowing. Under moderate and sever salinity levels both antioxidants alleviated the harmful effects of salinity on leaf senescence related parameter. The higher levels of antioxidants (ascorbic acid, phenol, carotenoids) and low level of H₂O₂ in flag leaf may be the prerequisite for delayed leaf senescence in antioxidants-sprayed plants. It can be concluded that ascorbic acid- sprayed plants can postpone the leaf senescence by peroxide/phenolic/ascorbate system which is involved in scavenging the ROS produced during leaf senescence.