Molokhia (Corchorius olitorius) is a common edible and famous vegetable in Egypt has high nutritive value as well as antioxidant compounds. Therefore the protective effects of molokhia against organephosphorous pesticide (malathion) - induced hepatotoxiclty in rats were studied. The results revealed that administration of malathion (20ppm) for 4 weeks. significantly depleted glutathione content (GSH). total protein (TP) and albumin. elevated glutathione-S-transferase (GST). alanine aminotranferase (ALT). aspartate aminotranferase (AST) and alkaline phosphatase (ALP) activities (Ps0.05).However. the intake of molokhia (100mgfkg body weight) alone or molokhia supplemented to malathion treated group significantly alleviated GSH. TP and albumin depletion and the elevation of GST. ALT, AST and ALP activities (P<0.05). These results indicate malathion- induced hepatotoxicity and highlight the protective action of molokhia as a potential protective agent against malathion induced hepatotoxicity. suggesting that molokhia contains specific active compound(s) or the considerable amounts of general compounds possessing the antagonistic (phenolic c ampeunds. vitamin A. Vitamin C and chlorophyll).