In this study, the physicochemical characteristics of camel's milk (CM) obtained from different arid and semi-arid regions in Egypt, including Aswan, Luxor, and Shalateen, were investigated. No significant differences were recorded in pH values. Significant differences were recorded in the titratable acidity (%). The milk samples collected from Luxor area had the highest value. Significant differences were recorded in total solids (TS) content between the camel milk samples. The camel milk samples collected from Aswan area have the highest values in fat, protein, and ash content. For the Luxor, Aswan, and Shalateen regions, antioxidant activity (%) and total phenolic compound content were 77.31, 69.14, 73.94%, and 1.48, 1.60, and 1.74 mg/100 g, respectively. In raw camel milk (CM), vitamin C content was recorded at 24.9, 26.03, and 21.92 mg/100g for the Luxor, Aswan, and Shalateen regions, respectively. On the other hand, the results were 13.69, 14.31, and 12.05 for the Luxor, Aswan, and Shalateen regions, respectively, after the pasteurization process. The amounts of K and Na were 1132, 1321, 1217, and 574, 702, and 621 mg/100g for the Luxor, Aswan, and Shalateen regions, respectively.