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204810

EFFECT OF CARROT AND WHEAT GERM OIL SUPPLEMENTATION ON RATS EXPOSED TO BENZENE

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Last updated: 04 Jan 2025

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Abstract

Benzene is an aromatic hydrocarbon. It gives rise to the production of oxygen radicals or reactive oxygen species (ROS), which are the means of the metabolic activation of benzene and are the source of its toxicity. This study was conducted to assess the ability of some food stuffs such as carrot and wheat germ oil to protect against benzene toxicity.Experiments were carried out on albino rats injected with benzene (0.5ml/kg body weight ip) and given diet supplemented with carrot and wheat germ oil. The dietary consumption and growth rate were measured. Several biochemical parameters representing antioxidant status were followed. The results showed that food intake and body weight gain of rats injected with benzene were significantly lower than that of control rats. Plasma malondialdehyde was increased and the levels of vitamins A & E and the activity of the antioxidant enzymes were decreased in rats injected with benzene. Supplementation with carrot and wheat germ oil caused a significant decrease in plasma malondialdehyde and significant increase in the level of vitamins and the antioxidant enzymes. The histopathological examination of the liver tissues of animals injected with benzene showed different lesions but supplementation with carrot and wheat germ oil caused an improvement in liver as compared with the benzene group. This study indicates that the toxic effect of benzene exposure can be partially corrected by food ingredients such as carrot and wheat germ oil. It is recommended to be given to individuals who are exposed to environments polluted with benzene.

DOI

10.21608/jfds.2007.204810

Keywords

Benzene, exposure, Carrot, Wheat germ oil, rat

Authors

First Name

Zeinab

Last Name

Saleh

MiddleName

A.

Affiliation

Food Sci. and Nutrition Dept., National Research Centre, Dokki, Cairo, Egypt.

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Orcid

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First Name

Khadiga

Last Name

Ibrahim

MiddleName

S.

Affiliation

Environmental and Occupational Medicine Dept. National Research Centre, Dokki, Cairo, Egypt.

Email

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City

-

Orcid

-

First Name

A.

Last Name

Farrag

MiddleName

H.

Affiliation

Pathology Dept., National Research Centre, Dokki, Cairo, Egypt.

Email

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City

-

Orcid

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First Name

Eman

Last Name

Shaban

MiddleName

E.

Affiliation

Environmental and Occupational Medicine Dept. National Research Centre, Dokki, Cairo, Egypt.

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City

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Orcid

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Volume

32

Article Issue

12

Related Issue

28859

Issue Date

2007-12-01

Receive Date

2021-11-15

Publish Date

2007-12-01

Page Start

10,153

Page End

10,165

Print ISSN

2090-3650

Online ISSN

2090-3731

Link

https://jfds.journals.ekb.eg/article_204810.html

Detail API

https://jfds.journals.ekb.eg/service?article_code=204810

Order

3

Type

Original Article

Type Code

886

Publication Type

Journal

Publication Title

Journal of Food and Dairy Sciences

Publication Link

https://jfds.journals.ekb.eg/

MainTitle

EFFECT OF CARROT AND WHEAT GERM OIL SUPPLEMENTATION ON RATS EXPOSED TO BENZENE

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Article

Created At

22 Jan 2023